Biological Variation of Holo-Transcobalamin in Elderly Individuals
نویسندگان
چکیده
منابع مشابه
Biological Variation of Holo-Transcobalamin in Elderly
Individuals, Andrew McCaddon, Peter Hudson, Cherie McCracken, Richard Ellis, and Anne McCaddon ( University of Wales College of Medicine, Division of General Practice, Wrexham LL13 7YP, UK; 2 Department of Pathology, Wrexham Maelor Hospital, Wrexham LL13 7TD, UK; 3 University Department of Psychiatry, Royal Liverpool University Hospital, Liverpool L69 3GA, UK; 4 University Hospital of Wales, Ca...
متن کاملFirst trimester serum levels of the soluble transcobalamin receptor, holo-transcobalamin, and total transcobalamin in relation to preeclampsia risk.
BACKGROUND Human placenta expresses CD320, a receptor that ensures the uptake of holo-transcobalamin (holoTC). Soluble CD320 (sCD320) is present in the circulation and its concentration increases during pregnancy. AIMS To investigate a possible association of sCD320, holoTC and total transcobalamin (TC) with the risk of subsequent preeclampsia using serum samples from asymptomatic first trime...
متن کاملDirect assay for cobalamin bound to transcobalamin (holo-transcobalamin) in serum.
BACKGROUND Only cobalamin carried by transcobalamin (holo-transcobalamin) is available for cellular uptake and hence is physiologically relevant. However, no reliable or accurate methods for quantifying holo-transcobalamin are available. We report a novel holo-transcobalamin assay based on solid-phase capture of transcobalamin. METHODS A monoclonal antibody specific for human transcobalamin w...
متن کاملQuantification of holo-transcobalamin, a marker of vitamin B12 deficiency.
Vitamin B12 Deficiency, Ebba Nexo, 1* Anna-Lisa Christensen, Anne-Mette Hvas, Torben E. Petersen, and Sergey N. Fedosov ( Department of Clinical Biochemistry, Aarhus University Hospital, DK-8000 Aarhus C, Denmark; 2 The Laboratory for Protein Chemistry, University of Aarhus, DK-8000 Aarhus C, Denmark; * address correspondence to this author at: Department of Clinical Biochemistry, AKH, Aarhus U...
متن کاملCharacterization of a monoclonal antibody with specificity for holo-transcobalamin
BACKGROUND Holotranscobalamin, cobalamin-saturated transcobalamin, is the minor fraction of circulating cobalamin (vitamin B12), which is available for cellular uptake and hence is physiologically relevant. Currently, no method allows simple, direct quantification of holotranscobalamin. We now report on the identification and characterization of a monoclonal antibody with a unique specificity f...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2003
ISSN: 0009-9147,1530-8561
DOI: 10.1373/49.9.1542